Present investigations were carried out on the effect of ethanol extract of Desmodium velutinum stem on some liver enzymes of albino wistar rats fed with high fat from cow‟s brain. Twelve healthy albin groups. Group I rats were fed with balanced diet ( mash) and tap water. Group II rats wer alone. Group III rats received combine 30% ethanol extract of Desmoduim elutinum stem (2.7g/day), Group IV rats were
fed with fat diet (cow‟s brain) and w (5mg/rat/day). The rats were sacrificed at the end of the experimental (two weeks) period. The plant extract was screened for its phytochemical constituents, using standard procedures. Phytochemical screening revealed the presence of tannins, flavonoids, saponins and alkaloids. The liver function tests was assessed by measuring the total bilirubin, total serum protein, direct and indirect bilirubin and liver enzymes such as Alanine amino transferase (ALT), Aspartate amino transferase (AST), Alkaline phosphate (ALP), Gamma-glutamyl transferase (GGT) on the liver of the albino wistar rat. The serum, ALT, ALP, AST and bilirubin concentration of the albino wistar rat increased significantly (P>0.05) compared to their total protein concentration. The result obtained indicate that the ethanol extract of Desmodium Velutinum stem possess hepatoprotective activity on the fatty liver of albino wistar rat fed with fat from cow‟s brain. The studied amount of phytochemicals including flavonoid, alkaloid, saponin, tannins, terpenoid
which were determined quantitatively using literature methods. The significant effect of the Desmodium velutinum stem ethanol extract was compared with standard drug, atorvastatin. The result in the present study suggest that the ethanol extract of Desmodium velutinum stem can be used in treating liver diseases.