This study investigated the roles of sex and parents’ level of education on self-esteem. The participants were Two hundred (200) students of Psychology and Political Science Departments of Nnamdi Azikiwe University, Awka within the age range of 18 and 39, with a mean age of 22.5 and a standard deviation of 3.12. The index of self-esteem (ISE) was used to measure the self-esteem status of participants. Results of the data using Three-Way ANOVA showed that (1) No significant difference was found between male and female students on self-esteem F (1,192) = 2.49, P = .12 (2) No significant difference between students whose father have higher education and students whose father have lower education on self-esteem F (1,192) = .02, P > .01 (3)No significant difference was also found between students whose mother have higher education and students whose mother have lower education on self-esteem F (1,192) = .05, P > .01. Discussion highlighted the necessity of encouraging self-esteem enhancement scheme in schools and families and the need to look at other individual’s attributes that may influence self-esteem. The implications of these results were discussed as well as some recommendations.