The rising wave of incidence of commercial sex work has given serious concern to the government, parents, health workers and the society. The causes and effects of commercial sex work among AkwaIbom girls in Uyo Local Government is the main concern of this study. The study seeks to find out the possible ways in which the problem of commercial sex work can be eradicated in the society. The study was empirically conducted where data was obtained through the primary and secondary sources. Instrument for data collection was questionnaire. Data was collected and analysed with simple percentage while the hypothesis stated were tested with percentage(%). The result in hypothesis one showed that, commercial sex work has implication on our general sexual health or wellbeing, that is the act of sex work has a negative effect on our sexual being. This hypothesis was accepted. In hypothesis two, which states that sex work is more likely to be caused by poverty. Based on the result, hypothesis two was therefore not accepted. Based on the result of this study a number of recommendations were made.