This study evaluated the antilipidemic activity of water extracts from leaves of Desmodium velutinum on albino wistar rats. The phytochemical analysis of the leaf extract showed the presence of tannins, saponins, alkaloids, soluble carbohydrates, flavonoids, reducing sugar, steroids, cyanide and terpenoids. The animals were treated with known drugs (atorvastatin 2ml). There were significantly reductions in HDL 13.00 1.41 mg/dl LDL 1.20 0.14 mg/dl and triglyceride 39.00 0.14 mg/dl, compared with water extract of Desmodium velutinum (0.5ml). when administered was found to significantly reduce lipid plasma which was LDL 1.90 0.00mg/dl, triglyceride 50.00 0.00mg/dl and increase HDL 25.00 0.00 mg/dl which is the good cholesterol. The water extract of Desmodium velutinum leaf can possibly normalize the plasma lipid when compared with the group given atorvastatin. The phytochemicals analysis showed that the association between these complexes and compounds and other constituent play an important role in the biological activity of the leaf. This study suggested that the water extract of D.velutinum leaf posses hypolipidemic as well as antilipidemic effect.